Here are some Python GUI frameworks.
Kivy is a python framework that is used in order to create attractive user interfaces. It supports lot of platforms namely Windows, MacOSX, Linux, Android iOS and Raspberry Pi. It is open source framework and it has about 20 widgets in its toolkit when you download it.
PyQT is a cross-platform Python binding framework. Currently, PyQT is available for Unix/Linux, Windows, Mac OS X and Sharp Zaurus. It is the combination of Python and Qt and it up to the programmer to decide whether to create a program by coding or using Qt Designer to create visual dialog. That is why it is called PyQt.
Tkinter is a inbuilt GUI Framework with Python, using Tk and is Python’s standard GUI framework. It is well know for its graphical user interface. It is open source and available under the Python License. One of the advantages of choosing Tkinter is that since it is inbuilt, there is an abundance of resources, both codes and reference books.
WxPython is an open source for cross-platform GUI library WxWidgets (earlier known as WxWindows) and implemented as a Python extension module. With WxPython you as a developer can create native applications for Windows, Mac OS and Unix.
PyGUI is a graphical application cross-platform framework for Unix, Macintosh and Windows. Compared to some other GUI frameworks, PyGUI is by far the simplest and lightweight of them all.