A nootropic is a substance that, if used properly, safely enhances the cognitive functions of the user.
As public interest in cognitive enhancers escalates, the demand for high-quality evidence on the safety and efficacy of nootropics seems to outgrow the supply of that information. Although new placebo-controlled studies are published frequently, they can be hard to read and misrepresentative of the entire body of knowledge the scientific community has provided on the effects of nootropics. These are some of the reasons why we systematically went through 527 placebo-controlled studies [1] on the effects of 127 nootropics and put together a list with the 5 most science-backed ones for improving memory. If a nootropic was not included in this list, it doesn’t necessarily mean it’s ineffective for improving memory. It likely means there is less research on the effects of that compound in healthy humans than there’s for each nootropic that made it on to the list.
Out of the 527 studies, 68 included measures of memory. A total of 5726 participants had their memory tested, and 24 nootropics were assessed for safety and efficacy for improving memory. Based on this body of evidence, these are the 5 most science-backed nootropics for improving memory in healthy humans.
Bacopa Monnieri
In the 11 studies we reviewed which examined the effects of Bacopa Monnieri on measures of memory, 500 participants were included. [2-12]
Overall, these studies found a small positive effect on memory from use of Bacopa Monnieri.
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